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UNIV - Staff Scientist I - Pharmacology

Apply now Job no: 540950
Entity: MUSC University
Department: COLLEGE OF MEDICINE - COM-Pharmacology
Sub Department: UNIV-2251000-Cell & Molecular Pharmacology
Work type: Full-Time
Employee Type: UNIV - Research Grant
Location: Charleston, SC
Categories: Research
Pay scale: UNIV-Band 6: $41,778.00 - $59,538.50 - $77,299.00 (min - mid - max)

FLSA: Salaried

 

Payscale Salary Range: UNIV-Band 6: $41,778.00 - $59,538.50 - $77,299.00 (min - mid - max)

 

Job Summary: The Pharmacology department is currently recruiting for a Staff Scientist I. A Staff Scientist is needed to coordinate and perform translational imaging MS studies in breast cancer across imaging and mass spectrometry platforms. Join a thriving collaborative and innovative group working at the nexus of lipidomics, glycomics, and proteomics for pre-clinical and clinical cancer prognostics and diagnostics.

Conduct proteomic and glycomic investigations into cellular and molecular mechanisms of breast cancer underlying hypoxic and ER stress. Studies will apply new techniques in imaging mass spectrometry to include integration and multiplexing of data from FT-ICR, QToF, CyTOF, immunostaining, pathology staining, confocal microscopy and other biological spatial aspects of breast cancer progression. Other aspects of the study include investigations on pre-clinical trial treatment regiments, dose-dependent response to target molecules to include library screening. Work includes development and use of clinical assays on tissues, cells or biofluids for cancer prognostics and diagnostics from basic methodology to biomarkers. Collaborative teams are composed of clinicians, clinician-scientists, pathologists, biochemists, mass spectrometry vendors, and basic researchers. Assist and train undergraduate, graduate, medical students, postdocs, and visiting scholars.

Designing, coordinating and performing imaging mass spectrometry studies on breast cancer tissues and cells. Design of standardization, appropriate system suitability tests, integration and or multiplexing with immunostaining. Instrument maintenance, tuning and upkeep, including instruction of such to students, postdocs and visiting scholars. Data analysis to include SCiLS Lab  (Bruker), R statistics.

 

Job Duties: 

  • 25% - • Tissue culture of primary tumor cell lines and maintain tissue culture of transformed cancer cell lines - (Essential)
  • 25% - • Performance of immunology techniques, including enzyme linked immunosorbent assay, cell proliferation assays, cytokine assays, flow cytometry - (Essential)
  • 15% - • Work closely with PI and collaborators to work on manuscripts and develop new research grant proposals - (Essential)
  • 10% - • Other duties include preparation of reagents; maintaining correct up to date laboratory notebooks, compliance with biosafety regulations, protection of human subjects and laboratory animal regulations; ordering supplies; and maintaining lab equipment - (Essential)
  • 10% - • Oversee and assist technicians, graduate students, visiting scholars and post docs involved in imaging research - (Essential)
  • 10% - • Perform data analysis from large imaging data sets - (Essential)
  • 5% - • Complete by protocol various molecular biology, cell biology, and biochemistry techniques, including Western blotting, quantitative PCR, agarose and acrylamide gel electrophoresis, protein purification, RNA isolation - (Essential)

 

Preferred Experience & Additional Skills: Proteomic MS/MS interpretation, proteomic pipelines, genomic data analysis, bioinformatics, R statistics, classification algorithms, machine learning, database creation and integration. Knowledge and skills on other cancer processes including hepatocellular carcinoma, lung adenocarcinoma prostate adenocarcinoma, colon adenocarcinoma are a plus. 

 

Minimum Experience and Training Requirements: A PhD, MD or equivalent with two years post-doctorate experience.



Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 30 lbs., unassisted. (Frequent) Ability to lift objects, up to 30 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 30 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 50 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 30 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Must be ambidextrous. Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent)

 

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.


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Applications close: Eastern Standard Time

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The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.