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Research Fellow - Molecular and Cell Biology

Job No.: 589977

Location: Clayton campus

Employment Type: Full-time

Duration: 12 month fixed-term appointment

Remuneration: $68,040 - $92,343 pa Level A (plus 9.5% employer superannuation)

  • Develop your own research program at one of the world’s top 80 universities

The Davidovich lab is located within Monash University — the largest university in Australia and among the top ranked institutes in the country — and is part of the EMBL Australia Partner Laboratory Network. We wish to understand how repressed genes are maintained transcriptionally inactive during development. At the molecular level, we study the recruitment and regulation of chromatin-modifying complexes.

The Opportunity

An excellent opportunity exists for a full-time Research Fellow to join an innovative research program within the Department of Biochemistry and Molecular Biology.  

The Project

The successful candidate will lead a project aiming to determine how histone modifiers maintain genes in an off-state during development — a process often referred to as 'epigenetic repression'. Specifically, the project will aim to understand how the robustness of epigenetic repression is achieved at the molecular level, to what extent it is essential in order to maintain cell identity and how it is dysregulated in disease.

Environment and Resources

The successful candidate will be encouraged to utilise and develop cutting-edge technology, including single-cell RNA sequencing, forward genetic screens (including CRISPR screens), mass spectrometry-based proteomics, electron cryotomography and genome editing combined with functional assays and standard genomic applications as ChIP-seq, HiC, ATAC-seq and RNA-seq. The successful candidate will have access to world-class research platforms at Monash University and High-Performance Computing (HPC) server for data analysis. This study will complement other ongoing studies in the lab — led by other scientists — including structure determination of macromolecular complexes of epigenetic modifiers and chromatin using high-resolution cryo-EM and electron cryotomography, and quantitative biophysical and biochemical functional assays.

The Candidate's Attributes

We are looking for a highly motivated cell or molecular biologist with an outstanding publication track record, relative to opportunity, in studying transcriptional regulation and who is capable and willing to develop their own research program within the lab. The successful candidate must have the following qualifications:

  • Hands-on experience with methods to study transcription and/or epigenetic regulation using mammalian cell cultures, including the implementation of next-generation sequencing techniques. Ideally, these would include some of the following methods: RT-qPCR, RNA-seq, ChIP-qPCR, ChIP-seq, iCLIP/PAR-CLIP, RIP, IP, IP with MS

  • Hands-on experience in the generation of constructs and stable cell lines for the study of transcription regulation or epigenetics in cells. Ideally, these would include the utilization of genome-editing approaches using CRISPR-Cas9 for a knock-out, knock-in and rescue experiments

The Candidate's Responsibilities

  • Develop their own research program in the lab under minimal supervision and mentorship that will be given by the Group Leader
  • Supervise students in the lab and to apply for fellowship applications and competitive funding, when applicable
  • Develop and utilise cutting-edge approaches in cell and molecular biology, but work in the lab would also potentially include the usage of lentiviruses and radioisotopes while complying with OHS guidelines
  • Generate results and write manuscripts that will be published as research papers in high-quality journals

The successful incumbent will possess a doctoral qualification in the relevant discipline or a closely related field

This role is a full-time position; however, flexible working arrangements may be negotiated.

At Monash University, we are committed to being a Child Safe organisation. Some positions at the University will require the incumbent to hold a valid Working with Children Check.

Your application must address the selection criteria. Please refer to "How to apply for Monash Jobs".

Enquiries

Associate Professor, Chen Davidovich, Laboratory Head, +61 3 9905 5702 

Position Description

Download File Post-Doctoral Research Fellow - Biochemistry and Molecular Biology

Closing Date

Tuesday 11 June 2019, 11:55 pm AEST

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