Applications are invited for appointment as Post-doctoral Fellow in the Department of Orthopaedics and Traumatology, School of Clinical Medicine (Ref.: 534147), to commence as soon as possible for one to three year(s), with the possibility of renewal subject to satisfactory performance.
Research Context & Project Background
The Department of Orthopaedics of Traumatology, School of Clinical of Medicine is seeking a highly motivated and talented Post-doctoral Fellow to join our multidisciplinary research team focusing on the molecular mechanisms of musculoskeletal diseases, including intervertebral disc degeneration (IVDD) and rare bone diseases like Pseudoachondroplasia (PSACH). Given that skeletal disorders often involve complex "ER storage" pathologies and genetic mutations, our research aims to bridge the gap between clinical observation and molecular therapy.
The successful candidate will leverage the unique clinical resources of the Greater Bay Area and the advanced research facilities at the University to develop innovative treatments.
Duties and Responsibilities
- Design and conduct experiments involving molecular biology, genetics, and gene editing (e.g., CRISPR/Cas9) to model orthopedic pathologies.
- Manage and perform functional studies using animal models (e.g., transgenic mice) to evaluate disease progression and therapeutic efficacy.
- Utilize induced pluripotent stem cell (iPSC) technology to create disease-in-a-dish models for high-throughput screening.
- Perform sophisticated transcriptomic data analysis (e.g., RNA-seq, single-cell RNA-seq) to identify novel biomarkers and therapeutic targets.
- Prepare high-quality manuscripts for publication in international peer-reviewed journals.
- Assist in the supervision of postgraduate students and junior research staff.
Requirements
- A Ph.D. degree in Molecular Biology, Genetics, Biotechnology, or a related field.
- Strong hands-on experience in gene editing and animal model handling.
- Proficiency in bioinformatics tools for transcriptomic data analysis is highly preferred.
- A solid publication record in reputable international journals.
- Excellent communication skills and the ability to work independently as well as collaboratively within a team.
- Experience in musculoskeletal research or bone biology will be considered an advantage.
Remuneration and Benefits
A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits.
Application procedure
The University only accepts online applications for the above post. Applicants should apply online and upload an up-to-date C.V., a cover letter stating their research interests and experience, and the contact information of at least three referees. Review of applications will start from January 26, 2026 and continue until February 13, 2026, or until the post is filled, whichever is earlier.
